Extract of Curcuma longa in the treatment of radiation lesions

author

  • M Rezvani
Abstract:

Reactive oxygen species (ROS) have been indicated in the development of diseases such as cancer, cardiovascular diseases, degenerative diseases and ageing. An increasing body of evidence indicates an association between increased and persistent oxidative stress and the development of radiation damage in tissues such as skin, central nervous system and kidney. On the basis of the new hypothesis i.e. the involvement of oxidative stress in the development of radiation-induced normal tissue lesions, an antioxidant drug has been developed. This consists of Curcumin and vitamin E. Curcumin is a phenolic antioxidant and anti-inflammatory initially isolated from the rhizome of the plant Curcuma longa Linn. It inhibits lipid peroxidation including radiation-induced lipid peroxidation. The efficacy of this combination drug has been tested in a number of biological models of radiation damage. This drug significantly reduced the incidence of radiation-induced myelopathy in a rat model. Radiation myelopathy is a rare but severe normal tissue damage that develops as a result of demyelination of individual nerve fibres. The lesions progresses with demyelination and eventual white matter necrosis that results in paralysis. In addition, the drug significantly reduces the incidence of radiation-induced mucositis. With single doses of radiation, a significant dose modification factor (DMF) of 1.24±0.06 was obtained. Radiation-induced mucositis of upper aerodigestive tract is a major dose-limiting factor in the treatment of head and neck tumours that develops as a consequence of the depletion of the stem cells of the epithelial lining of the mucosa. With a more clinically relevant fractionated irradiation schedule, the DMF increases to a remarkably high level of 1.44±0.08. It is concluded that the antioxidant compound consisting of the extract of Curcuma longa and ? ?-tocopherol has great potentials in the treatment of radiation-induced normal tissue lesions.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

the effect of aqueous extract of garlic on formalin-induced pain in male rats

چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...

15 صفحه اول

Evaluation of Skin Colouring Properties of Curcuma Longa Extract

The aim of this study was to evaluate the skin colouring properties of curcuma extract in cosmetic formulations. Objective measurements of the skin colour changes were done by Chromameter using the CIE L*a*b* colour space parameters. These measurements were correlated with the results of the sensory analysis. The observations showed permanent, visible and statistically significant changing of b...

full text

Curcuma longa

Description Curcuma longa, a perennial herb and member of the Zingiberaceae (ginger) family, grows to a height of three to five feet and is cultivated extensively in Asia, India, China, and other countries with a tropical climate. It has oblong, pointed leaves and funnel-shaped yellow flowers.1 The rhizome, the portion of the plant used medicinally, is usually boiled, cleaned, and dried, yieldi...

full text

Pharmacology of Curcuma longa.

The data reviewed indicate that extracts of Curcuma longa exhibit anti-inflammatory activity after parenteral application in standard animal models used for testing anti-inflammatory activity. It turned out that curcumin and the volatile oil are at least in part responsible for this action. It appears that when given orally, curcumin is far less active than after i.p. administration. This may b...

full text

the effect of taftan pozzolan on the compressive strength of concrete in the environmental conditions of oman sea (chabahar port)

cement is an essential ingredient in the concrete buildings. for production of cement considerable amount of fossil fuel and electrical energy is consumed. on the other hand for generating one tone of portland cement, nearly one ton of carbon dioxide is released. it shows that 7 percent of the total released carbon dioxide in the world relates to the cement industry. considering ecological issu...

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume Volume 3  issue Supplement 2

pages  78- 78

publication date 2010-11-20

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023